Abstract:With the continuous advancement of the Healthy China strategy，the concept of food and medicine homology has attracted widespread attention. Isoflavone glycosides （IG），as key natural active components in food and medicine homology plants，are widely distributed and possess multiple physiological functions such as antioxidant and anti-inflammatory effects. The biological activities of isoflavone glycosides and their roles in the food and medicine homology system were systematically analyzed from the perspectives of molecular mechanisms，metabolic pathways and functional evaluations. Their synergistic effects with food and medicine homology matrices and application potential in the development of functional foods were also explored，aiming to promote their scientific application in the field of food and medicine homology and contribute to the progress of the health industry.