Abstract:Hyperuricemia （HUA） is a metabolic disorder arising from purine metabolism dysregulation. While current clinical drugs effectively lower uric acid levels， long-term administration often leads to adverse effects.Chrysanthemum morifolium flowers， rich in flavonoids， exhibit significant antioxidant and anti-inflammatory activities. This article systematically reviewed recent research progress in the mechanisms through which C.morifolium flavonoids managed HUA via multiple targets and pathways. Considering their favorable safety profile and functional properties， C. morifolium flavonoids presented a promising application prospect for the development of functional beverages aimed at reducing uric acid levels. This review was expected to offer new perspectives for utilizing natural plant-based therapeutics in the prevention of metabolic diseases.