Abstract:Oxidative damage in the body is caused by excessive accumulation of reactive oxygen species（ROS） and other free radicals， which attack cells， tissue， or organs， leading to impaired functions. In recent years， food-derived natural products have become a focal point in the research of health science due to their significant antioxidant properties. Zebrafish， as an ideal live model organism， exhibit unique advantages in evaluation of the antioxidant effects of natural products. The research progress in seven different types of zebrafish models was reviewed and the applications of these models in the research on natural products and their underlying mechanisms were explored， with the aim of providing theoretical support for the development of novel antioxidant drugs.