Abstract:Egg white albumin （E）-epigallocatechin gallate （E-EGCG） non-covalent complex was prepared by the mixing method；then，the oral，gastric，and small intestinal digestion was simulated to determine the EGCG content and the scavenging rates of DPPH，ABTS+，and hydroxyl radicals before and after digestion of the E-EGCG non-covalent complex.The effect of EGCG mass concentration on the EGCG binding amount，EGCG bioavailability index，EGCG bioaccessibility，antioxidant activity，and bioavailability index of E-EGCG noncovalent complex was studied.The results showed that the EGCG binding amount，EGCG bioavailability index，and in vitro antioxidant activity in the E-EGCG non-covalent complex significantly increased （P<0.05） with the increasing EGCG mass concentration，reaching the maximum values of 1.207 mg/mg，0.637，68.31%（DPPH radical scavenging rate），89.32% （hydroxyl radical scavenging rate），and 84.00% （ABTS+ radical scavenging rate） at an EGCG mass concentration of 10.00 mg/mL.Compared to the free EGCG at the same concentration （1.25 mg/mL），the EGCG in the E-EGCG non-covalent complex exhibited higher DPPH and hydroxyl radical scavenging rates，as well as higher bioaccessibility，and the hydroxyl radical scavenging rate of the digestive products was significantly increased after in vitro digestion.