Abstract:Folic acid plays a crucial role in cell proliferation，DNA synthesis，and the maintenance of human health.A deficiency in folic acid is closely associated with neural tube defects in newborns，megaloblastic anemia，and the occurrence of various malignant tumors.However，due to the instability of folic acid，its loss rate is relatively high during food processing.Through folic acid fortification techniques such as fermentation，microencapsulation，and genetic engineering，the folic acid content in food or feed can be significantly increased，ensuring its stability and bioavailability.This article provides a comprehensive review of the technical path of folic acid fortification，its application in food industry and its development direction offering references for technological upgrades in related industries and the development of high-quality nutritional foods.