Abstract:To investigate whether Coral dealbatus extract can alleviate the fat accumulation in mice fed a highfat diet，36 C57BL∕6J mice were selected for this experiment，with 6 mice in each group.The mice were fed a high-fat diet supplemented with the aqueous extract，aqueous-alcohol precipitation extract，and aqueous-alcohol soluble C.dealbatus extract，respectively.A low-fat diet group and a metformin positive control group were also established as controls.The experiment lasted for 16 weeks，during which the extracts and metformin were administered via drinking water.Growth indicators of the mice were monitored weekly，and at the end of the feeding period，certain biochemical indicators were measured，and histopathological examinations were performed on the liver tissues.The results showed that the aqueous extract of C.dealbatus effectively reduced the body weight of mice on a high-fat diet and significantly decreased their epididymal fat pad index.The aqueousalcohol precipitation extract effectively reduced the inguinal fat pad index and epididymal fat index in mice，while also lowering their serum low-density lipoprotein cholesterol levels.The aqueous-alcohol soluble extract significantly reduced serum triglyceride levels in mice.Liver staining results indicated that the aqueous extract，aqueous-alcohol precipitation extract，and aqueous-alcohol soluble C.dealbatus extract all had certain ameliorative effects on hepatic lipid accumulation in mice.In conclusion，C.dealbatus extract demonstrates a mitigating effect on lipid accumulation in mice fed a high-fat diet.