Abstract:Mulberry leaves with both medicinal and edible properties are widely distributed in China，showcasing rich resources. Mulberry leaf polysaccharides（MLP），as a natural product with multiple biological activities，have received extensive attention in recent years. MLP has good antioxidant，blood glucose- and lipidlowering，immunomodulatory，and gut microbiota-regulating effects. The research progress in MLP was reviewed from four aspects: extraction and purification technology，structural characterization，biological activities，and structure-activity relationship，with a view to providing references for the further research and development of MLP in the fields of medicine and functional foods.