Abstract:This study utilized snow pears and Nanguo pears as the main raw materials,supplemented with tangerine peel,hawthorn and roselle,to develop a compound pear soup beverage with digestion promoting effect.The formulation and processing parameters were optimized through single-factor experiments and orthogonal design experiments.By employing sensory evaluation scores as the principal assessment criteria,and combining with quantitative analysis of total phenol content,total flavonoid content,and antioxidant capacity,the optimal processing conditions were determined.To investigate the pharmacological effects of this beverage in promoting digestion,network pharmacology approaches were implemented to identify and predict the potential targets of digestion promoting active ingredients,with particular emphasis on the targets associated with functional dyspepsia （FD）.The results showed that the optimal processing conditions for the compound pear soup beverage were as follows：a stewing duration of 30 minutes,with tangerine peel,hawthorn and roselle additions at 2.0%,1.4% and 0.6%,respectively.Under these conditions,the total phenol content of the compound pear soup beverage was 94.75 mg/L,the total flavonoid content was 112.5 mg/L,the 1,1-diphenyl-2-picrylhydrazyl（DPPH） free radical scavenging rate was 89.5%,the hydroxyl radical scavenging rate was 76.4%,and the ferric ion reducing ability was 0.82.A total of 592 active ingredients and 310 common targets were identified in compound pear soup beverage.Phosphatidylinositol 3-kinase regulatory subunit 1（PIK3R1）,protein kinase B（AKT1）,epidermal growth factor receptor （EGFR）,steroid receptor coactivator （SRC）,mitogen-activated protein kinase kinase 1 （RAF1） and other targets were the core targets of the compound pear soup beverage for treating FD.The predominant signaling pathways implicated in these mechanisms comprised the phosphatidylinositol 3-kinase-protein kinase B（PI3K-AKT1） pathway,lipid metabolism and atherosclerosis pathway,and advanced glycation end products and receptor for advanced glycation end prodncts（AGE-RAGE） signaling pathway.The mechanism of the compound pear soup beverage with tangerine peel,hawthorn and roselle in treating FD might be principally mediated through the enhancement of gastrointestinal function.