Abstract:The extraction process of raw materials for the preparation of Zhigan oral liquid was optimized with the comprehensive score of total flavonoids，total polysaccharides，dihydromyricetin，irisin，and kakkalide as the evaluation index. On the basis of single factor test results，water volume folds （A），decocting time （B），and decocting times（C） were selected as influencing factors. The criteria importance though intercrieria correlation （CRITIC） method and the independence weight coefficient method were combined with the response surface method to optimize the extraction process. The influences of different factors on the comprehensive score followed the trend of decocting times＞water volume folds＞decocting time. The CRITIC method predicted that the optimal extraction process was as follows：water volume folds of 9.313 44，decocting time of 1.064 29 h，and decocting times of 2.852 659，under which the oral liquid showed the comprehensive score of 87.612 4 points.The optimal extraction process predicted by the independence weight coefficient method was as follows：water volume folds of 9.531 22，decocting time of 1.046 15 h，and decocting times of 2.446 429，under which the oral liquid showed the comprehensive score of 87.906 6. According to the actual production condition，the extraction process was adjusted as water volume folds 10，decocting time of 1 h，decocting times of 2，which was stable and feasible.