Abstract:With growing attention to health， the conventional "single-component， single-target" research paradigm has become inadequate for analyzing the synergistic effects of multiple food functional factors. Network pharmacology， leveraging multi-omics， big data， and bioinformatics， offers a systematic approach for constructing functional factor-target networks and enables comprehensive understanding of the bioactivities and mechanisms of functional factors. The research methodologies， analytical tools， current applications， limitations， and future directions of network pharmacology in the field of food functional factors were reviewed， with the aim to promote the continuous optimization and innovation of network pharmacology in this domain.Key words： network pharmacology； food functional factors； bioactivity； bioinformatics； mechanism