Abstract:To study the auxiliary protective effect of Puerariae-stewed rhubarb compound extracts on acute gastric mucosal injury induced by anhydrous ethanol in rats，60 rats were randomly divided into normal group，model group，and low-，medium-，and high-dose Puerariae-stewed rhubarb compound extracts groups.Each group consisted of 12 rats continuously gavaged for 32 days.In the last dosage，rats in each group were allowed to feed nothing but water for 24 h，and anhydrous ethanol was used for molding.The rats′ weight，the gastric injury score，the gastric mucosal injury degree，as well as the score of congestion，bleeding，epithelial cell degeneration and necrosis，and the total lesion score，were all recorded.Compared with the normal group，there was no significant difference in body mass between the model group and Puerariae-stewed rhubarb compound extracts groups（P＞0.05），while the gastric mucosa injury score in the model group was significantly higher（P＜0.05）.Compared with the model group，the medium-and high-dose Puerariae-stewed rhubarb compound extracts groups could reduce gastric congestion，bleeding，epithelial cell degeneration and necrosis，as well as the total histological lesion score（P＜0.01）.The high-dose group could significantly reduce the total score of acute alcohol damage to the gastric mucosa in rats（P＜0.05）.Puerariae-stewed rhubarb compound extracts have an auxiliary protective effect on the acute gastric mucosal injury model induced by anhydrous ethanol.