Abstract:Acetylation modification of polysaccharides is an important chemical modification means of polysaccharides. At present，the global studies of the acetylation of polysaccharides and the mechanisms of their hypoglycemic effects are missing a systematic summary，which is not conducive to the in-depth study of the acetylation of polysaccharides and the mechanisms of their hypoglycemic effects. Therefore，the preparation，identification，and hypoglycemic mechanism of acetylated polysaccharides were reviewed，with a view to improving the activities of polysaccharides in the future and providing a reference for further exploitation of natural polysaccharide resources.