Abstract:This article explored the lipid-lowering activity of Rosa roxburghii Tratt.Ethanol extracts and the mechanisms.After extracting Rosa roxburghii Tratt.，48 healthy adult Kunming（KM）mice were randomly divided into a normal group，a model group，high，medium，and low-dose R.roxburghii Tratt.ethanol extract groups，and a simvastatin group.The model group was given a high-fat diet for 30 d to induce the mouse model of food-induced obesity，and at the same time，corresponding drugs were given by gavage for 30 d.After 20 d of modeling，the body mass and dietary intake of mice in the model group were increased significantly as compared with the normal group（P<0.05)，and the body mass and dietary intake of mice in the high and medium-dose R.roxburghii Tratt.ethanol extract groups were significantly reduced as compared with the model group（P<0.05).The body mass of mice in the simvastatin group was significantly lower than that of the model group（P<0.05）after 30 d of modeling，and there was no significant difference in dietary intake.As compared with the model group，the serum total cholesterol（TC)，triglyceride（TG)，and low-density lipoprotein cholesterol（LDL-C）of mice in the high and medium-dose R.roxburghii Tratt.ethanol extract groups and the simvastatin groups were significantly reduced（P<0.05).The oil red O staining showed the hepatic fat content of mice in the R.roxburghii Tratt.ethanol extract groups and simvastatin group was significantly reduced.The results of the enzyme-linked immunosorbent assay（ELISA）showed that the serum leptin of mice in the model group was significantly higher than that of the normal group（P<0.05)，and the serum leptin of mice in the high and medium-dose R.roxburghii Tratt.ethanol extract groups was significantly lower than that of the model group（P<0.05).In conclusion，R.roxburghii Tratt.ethanol extracts can significantly reduce the body mass，dietary intake，and blood lipid content of food-induced obese mice，and its mechanism is related to the reduction of serum leptin in food-induced obese mice.