Abstract:The experiment aimed to investigate whether Lactobacillus paracasei TK1501 fermented soybean meal reduced the effects of streptozotocin（STZ）induced type 2diabetes using a mouse model.SPFgrade Kunming male rats（4-5 weeks of age）were randomly divided between four groups：a blank group，a model group，a L.paracasei TK1501 fermented soybean meal group，and an unfermented soybean meal group.Each group contained ten rats.A continuous intraperitoneal injection of STZ was administered for three days to establish the model prior to initiating the experiment.The experiment ceased after four weeks.Then were the body weight，blood sugar，glucose tolerance，liver glycogen，cholesterol，triglycerides，and organ histopathology were to determine whether L.paracasei TK1501 fermented soybean meal reduced the effects of STZ-induced typeⅡ diabetes in mouse.The results revealed the mice fed L.paracasei TK1501 fermented soybean meal possessed a significantly enhanced glucose tolerance（p＜0.05），significantly reduced：total cholesterol（p＜0.01），low-density lipoprotein cholesterol（p＜0.01），high-density lipoprotein cholesterol（p＜0.01），glycogen（p＜0.05）and positive effects on various other indicators.Simultaneously，the liver，kidney，and pancreas of the diseased mice provided L.paracasei TK1501 fermented soybean meal were significantly improved.L.paracasei TK1501 fermented soybean meal significantly relieves and causes therapeutic effects on type Ⅱ diabetes in mice.This research provides a reference for developing functional foods in our quest to lower blood sugar levels.