Abstract:The molecularly imprinted polymers prepared by molecular imprinting technology （MIT）has the characteristics of predestined specific recognition，good practicability and stability，etc.Therefore，it has been widely used in the field of food safety detection.This paper reviewed the basic concepts and principles of MIT，as well as the research progress of MIT in the detection of pesticide residues，veterinary drug the application progress of molecular imprinting technology in the detection and application of food pesticide residues，veterinary drug residues，heavy metal pollution，additives and biological pollution，etc.，compared the advantages of molecular imprinting technology with traditional solid-phase extraction and analyzed its difficulties at present and development direction in the field of food safety detection.