Abstract:Nisin is a safe，highly effective，no side effect natural preservative.At present，many studies have shown that Nisin has a good inhibitory effect on the growth of pathogenic bacteria and microorganisms in plants and animals，and has certain research significance and application prospects，and has gradually become a new research hotspot.The different sources and production methods of Nisin were introduced.The antibacterial activity of Nisin and its research status in meat，dairy products，fruits and vegetables preservation and preservation were mainly introduced.The application prospect of Nisin was prospected，which provided a theoretical reference for its further research and comprehensive development and utilization.