Abstract:Red raspberry is rich in ellagic acid and its polymers and other compounds have hangover function.The cultivated raspberry oyster mushroom，added traditional medicinal plants，jujube，bitter buckwheat and stomach-raising effect millet was carried out the development of hangover tablets.The D-Optional method was designed by used the mixture in Design Expert（V.8.0.6）.The activation rate of in vitro alcohol dehydrogenase（ADH）was used as the evaluation index to design the best main ingredient of the wake-up chewable tablets.By established a regression model between the different ratios of each component and the activation rate of ADH，the effect of the interaction of each component in the formulation on the response value was investigated，used the software optimization function and verification test，the best main ingredient formula was that millet flour31.2% ，bitter powder21.7% ，20.5%of mushroom powder，16.8%of kudzu pollen，9.8%of jujube powder，under these conditions，ADH The activation rate was up to 15.87%，and the verification test results was consistent with the predicted values，indicated that the formulation process optimized by this method was stable and reliable.