Abstract:The process optimization for ultrasonic-assisted solvent extraction of flavonoids from quinoa seeds by response surface analysis was investigated in the study.On the basis of single factor test，the extraction time，temperature and ultrasonic power were selected for the three-factor，three-level central composite experimental design.Subsequently，the functional relation was established between the factors and the total content of flavone.Design Expect 8.0 software was employed to analyze the test data and the response surface method was applied to optimize the extraction conditions.The results indicated that the obtained optimum extraction conditions were as follows：extraction time 35 min，ultrasonic power 42 W，extraction temperature 59 ℃.Under these conditions，the extraction yields of total flavonoids from quinoa seeds reached 0.31%，which was well matched with the predicted content.Controlling the extraction temperature and time under the same condi－tions，the ultrasonic assist extraction was compared with thermal reflux extraction，with the content of total flavonoids as indicators.The results showed that the ultrasonic extraction was more superior，as the average extraction content of total flavonoids was 1.19 times that of thermal reflux extraction.