Abstract:Inductively coupled plasma mass spectrometry （ICP-MS）analysis method was established for the determination of inorganic elements in Cornus officinalis and the inorganic elements in Cornus officinalis from different producing areas were analyzed and compared.The samples were digested by microwave digestion.The contents of 22 inorganic elements in Cornus officinalis from different producing areas were determined by ICPMS.The data of variance analysis were analyzed with the SPSS20.0 software.The results showed that the contents of K，Ca，Mg，P，Na，Fe，Al，Zn，Cr，Mn，Ba，Sr and other elements in Cornus officinalis were rich.Among them，the contents of Na，Mg，Ca，Zn and Ba in Linan of Zhejiang were the highest，the contents of K and Al in Foping of Shaanxi were the highest，the content of Fe in Henan Nanzhao was the highest and the content of Sr in Henan Xixia was the highest.The heavy metal elements As，Cu，Cd，Hg，Pb met the limit standards.The variance analysis showed that most of the inorganic elements in the Cornus officinalis from Foping Prefecture of Shaanxi Province were significantly different from those in Zhejiang Linan，but there was no significant difference with most inorganic elements in the samples from Henan Province.And there were nosignificant differences in inorganic elements in the producing areas of Xixia，Luanchuan and Nanzhao in Henan Province.