Abstract:With ficus carica leaves as raw material，the ultrasonic-assisted extraction process parameters of total flavonoids from ficus carica leaves were optimized by response surface method.Based on single factor experiments，ethanol concentration，extracting times，solid-liquid ratio and ultrasonic power on extraction rate were investigated by taking ficus carica leaves as the raw material and using ultrasonic to assist in extracting the total flavonoids in ficus carica leaves.The results showed that the optimal extraction process was ethanol concentration 43 %，ultrasound time 42 min，solid-liquid ratio 1∶60（g/mL），ultrasonic power of 200 W.Under the above conditions，the total flavonoids yield of the ficus carica leaves was 3.519 %，the predicted extraction rate of total flavone was 3.522%，the predicted value was close to the actual measured value.Boxbehnken design combined with response surface analysis could optimize the extraction conditions of total flavones in ficus carica leaves.The research could be developed a theoretical foundation and a scientific basis for the extraction of total flavonoids from ficus carica leaves.