Abstract:The formulation of a hypoglycemic meal-replacement oat-based powder was studied and the content of active ingredients was determined.Firstly，oat flour，skimmed milk powder，black tartary buckwheat tea powder，Pueraria Radix powder，bitter mellon kernel powder，lotus root starch，xylitol，and stevioside were ground into a very fine powder and mixed together.Then，the formulation of the hypoglycemic meal -replacement powder was developed through sensory evaluation.Finally，the content of the main effective components in the formula was determined.When the contents of other components were fixed，the effects of different amounts of black tartary buckwheat tea powder，Pueraria Radix powder，and bitter mellon kernel powder were studied via single factor methodologies，and then their formulations were optimized using the Box-Behnken design.Study results showed that the amount of black tartary buckwheat tea powder，Pueraria Radix powder and bitter mellon kernel powder were respectively 8.0 g，16.0 g and 10.0 g，the sensory quality of the hypoglycemic meal-replacement powder was found to be the best.The puerarin content in this formulation was 2.68 mg/g，and the rutin content was 4.76 mg/g.The hypoglycemic meal-replacement powder tasted smooth and sweet，and it was nutritionally rich，making it suitable for use as an auxiliary food for people with high blood fat levels and diabetes mellitus.