Abstract:The effects of Apostichopus japonicus oligo-peptides on alloxan-induced diabetic mice were studied.The diabetic mice were induced by intraperitoneal injection of alloxan，and administered by oral gavage at different dose of Apostichopus japonicus oligo-peptides （0.1，0.2，0.5 g/kg）for 6 weeks.The body weight and content of fasting blood glucose （Glu）were detected on 0，2，4，6 weeks.The index of thymus，spleen，liver and kidney，the content of malondialdehyde（MDA）and the activity of superoxide dismutase（SOD）in serum were measured after last administration. The loss of body weight was obviously relieved （p<0.01）and the content of Glu were decreased（p<0.05）at middle and high dose of Apostichopus japonicus oligo-peptides.The concentration was positively correlated with the time. The high dose of Apostichopus japonicus oligo-peptides significantly increased the organ index of diabetic mice （p<0.05），decreased the content of MDA （p<0.05），and increased the activity of SOD in serum （p<0.01）. Apostichopus japonicus oligo-peptides can reduce the content of Glu，improve immunity and oxidative activity，and protect liver and kidney. It can infer that Apostichopus japonicus oligo-peptides reduce the content of Glu and prevent diabetic complications by increasing oxidative activity and immunity.