Abstract:Fifty Sprague-Dawley rats were randomly divided into normal group，model group，and low，middle，high dose group of proanthocyanidins resveratrol pulp intervention groups [0.5，1.5，4.5 g/（kg·bw）].Normal group was given normal saline in the same volume while other groups were given 52°liquor into stomach of rats to establish alcoholic brain damage model. Meanwhile，rats in low，middle，high proanthocyanidins resveratrol pulp groups were administered with corresponding foods once a day. After 8 days of gavage，weight gain ranges were calculated，and the activities of superoxide dismutase（SOD），glutathione peroxidase（GSH-Px）and Ca2+-Mg2+-ATPase，the suppression ability of hydroxyl free radical，and the contents of malondialdehyde （MDA），Ca2+were detected in brain homogenate，and the activities of SOD and the contents of MDA were also detected in serum. The effects of different doses of proanthocyanidins resveratrol pulp on alcoholic brain damage in rats were analyzed.The results showed that proanthocyanidins resveratrol pulp might have preventive protection effects on alcoholic brain damage by scavenging free radicals，increasing the activity of SOD，GSH-Px，Ca2+-Mg2+-ATPase and the suppression ability of hydroxyl free radical，decreasing the contents of MDA amd Ca2+，alleviating the mental and behavioral disorders，weakening the adverse effects of alcohol on appetite and gastrointestinal digestion.