Abstract:Abstract：A method for simultaneous determination of 11 synthetic colorants in vegetable products by solid phase extraction-high performance liquid chromatography was established.The synthetic colorants in vegetable products were extracted with 25%ammonia-ethanol，purified by the weak anionic solid phase extraction cartridges-Waters Oasis WAX，and separated on the Agilent 5 TC-C18（2）column using methanol∶acetonitrile（4 ∶1，volume ratio）and 0.02 mol/Lammonium acetate asmobile phase by gradient elution.The target compounds were detected by a multi-wavelength diode array detector，and quantified by an external standard method.The results showed that the 11 synthetic colorants had good linearities in the range of 0.2 μg/mL-40 μg/mL.The mean recoveries at 3 spiked levels of 1，2，10 mg/kg ranged from 87.5%to102.6%with RSDs（n=6）of 1.5%-5.8%.The detection limits were in the range of 5 μg/L-45 μg/L.This method can be used for the routine analysis of synthetic colorants in vegetable products.