Abstract:To study the effects of pine bark procyanidins extract on blood glucosein diabetic mice， to explore the related mechanism. Diabetic mice model was made by high fat diet combined with intraperitoneal injection of STZ. Diabetic mouse were randomly divided into model group， Glibenclamide group （250 mg/kg）， pine bark procyanidins extract high-dose group （400 mg/kg）， middle-dose group （200 mg/kg） and low-dose group （100 mg/kg）. Fasting blood glucose was measured after continuous intragastric administration 8 weeks. Blood samples were taken out from the tail of diabetic mice to measure fasting blood glucose； Then blood samples were taken out from the eyeball to measure IL-6 content， CRP content and blood lipid level. Pine bark procyanidins extract high and middle-dose group can significantly lower the blood glucose level in STZ induced diabetic mice （P<0.05）.Serum TG and TC content in pine bark procyanidins extract high and middle-dose group werelower than the model group significantly（P<0.05）.INS content in pine bark procyanidins extract high-dose group was higher than the model group significantly（P< 0.05）.Serum IL-6、CRP content in pine bark procyanidins extrac－ thigh and middle-dose group were lower than the model group significantly. Diabetic mice pancreatic tissue were repaired. The pine bark procyanidins extract had a significant effects on reducing blood glucose and im－ proving blood lipid level in STZ induced diabetic mice. The mechanism might be related to repairing pancreatic tissue， improving the INS and reducing the content of inflammatory factors in diabetic mice.