Abstract:High -fat diet induced oxidative stress and liver function injury in rats were effectively improved through investigating GABA-enrich rice bran. The natural rice bran was transformed into the GABA-enrich rice bran by virtue of aminobutyric acid enzyme， which was acquired by adding GABA precursor substance L-Glu－ tamic acid into it. It was clearly found that the content of GABA increased from 32 mg/100 g to 242 mg/100 g. Firstly， the natural rice bran and GABA-enrich rice bran were added into the high fat feedstuff respectively. Then， the effects of GABA-enrich rice bran on high-fat diet rats weight， liver function and even oxidative stress were studied， the experimental rats were divided into four categories - normal control group， high -fat feed group， natural rice bran， and GABA-enrich rice bran group. Finally， it was revealed that the rat weight in GA－ BA-enrich rice bran group was lower than high fat fee group rats and natural rice bran group rats （P<0.5）. Therefore， it was proved that the GABA -enrich rice was superior to the natural rice bran in reducing liver steatosis cells， aminotransferase， alkaline phosphatase and in improving liver oxidative stress.