Abstract:Meat and its by-products from livestock and poultry as a widely accessible protein resource con－ sumed worldwide were also a potencial resource of food-derived peptides. In this paper， the domestic and for－ eign research progress of common bioactive peptides in muscle， bone， blood， brain， knot hoof tissues and skin of livestock and poultry were reviewd. And biological characteristics of these peptides and their applications in human body system were introduced emphatically， at the same time， the generation mechanism， separation and purification， as well as identification technology were summarized. The aim of this study was to provide an idea for exploring the application study of bioactive peptides in meat and its by-products.