Abstract:This paper investigated the lipid-lowering and weight-reducing effects of chitosan oligosaccharide （CO） and resistant starch （RS） compound. This compound was made through cross -linked reaction after blending them together. Experimental rats were divided into 5 groups， including normal control group， high fat diet group and 3 different intervening groups， intervening groups were treated with CO （0.3 g/d·per rat）， RS （1.2 g/d·per rat） and compound （1.5 g/d·per rat）， normal control and high fat diet groups' rats treated with same volume distilled water. After 6 weeks， we measured rats' body weight， body fat， liver weight， blood glu－ cose and serum lipid levels， calculated liver index and body fat ratio. The results showed that CO and RS's com－ pound had synergistic effect. This compound could significantly decrease high fat diet rats' body weight， liver index， body fat ratio， serum insulin level（INS） serum total cholesterol（TC）， triglyceride（TG）， low density lipoprotein-cholesterol （LDL-C）（p<0.05） and recover towards normal diet rats' level. It showed good lipid-lowering and weight -reducing effects and the effects were better than that of resistant starch and chitosan oligosaccharide intervened alone.