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投稿时间：2016-09-20
投稿时间：2016-09-20
中文摘要: 探讨姬松茸多糖对小鼠免疫功能和抗疲劳作用的影响。 成年小鼠 40 只随机分为对照组、 姬松茸多糖低剂量 组、中剂量组和高剂量组，每组 10 只。分别以生理盐水、100、150、 200 mg/kg 浓度姬松茸多糖灌胃给药，持续 10 d，对小 鼠进行抗疲劳试验和相关免疫指标的测定。姬松茸多糖显著提高小鼠脾脏和胸腺指数（中剂量时 P＜0.05；高剂量时 P＜0.01）；姬松茸多糖显著提高小鼠脾脏和胸腺指数，增加小鼠血清中 IL-6 和 TNF-α 的含量，提高 CD4+、CD8+细胞计数； 并能延长小鼠常压耐缺氧时间和负重游泳时间，提高小鼠血清中 SOD 活性，降低 MDA 含量。姬松茸多糖增强能够小鼠 免疫功能和抗疲劳作用。
Abstract:To discuss the effect of the mice immune function and fatigue resistance about Agaricus blazei polysaccharide. We divided adult mice into 4 groups randomly. There were the control group， low-dose group， middle-dose group and high- dose group. Each group of them had ten mice. They were injected gavage admin－ istration by weight molal， such as 100， 150， 200 mg/kg. It continued 10 d， and then measured the anti-fatigue experiment and related immune index of these mice. According to this experiment， Agaricus blazei polysaccha－ ride promoted the index of spleen and thymus remarkably， increased the content of IL-6 and TNF-α in the mice serum， increased the cell count of CD4+ and CD8+， extended the time of normal pressure hypoxia and weight loading swimming， promoted the activity of the SOD in the mice serum， and reduced the contend of MDA.
文章编号：201705043 中图分类号： 文献标志码：A
基金项目:
| Author Name | Affiliation |
| LI Jing1， WEI Jian2，* | 1. Jilin Sports University，Changchun 130033， Jilin， China；2. Changchun Normal University ，Changchun 130032， Jilin， China |
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