Abstract:In this study，persimmon as raw material，the second rotatable experimental design Central-Composite to optimize the production process of buccal persimmon；by FRAP method，DPPH radical scavenging method，hydroxyl radical scavenging method comparative study of oral tablets and natural made of persimmon persimmon in vitro antioxidant activity.The results showed that the optimized production technology for the buccal tablet：in 2.5 mL persimmon juice concentrate，corn starch addition level 2.635 g，mannitol dosage of 0.504 g，sugar dosage of 0.442 g，0.836 g dosage of Chinese juice concentrate when 150 mg/mL oral tablet total antioxidant capacity of 86.98，hydroxyl radical scavenging rate was 85.40%，DPPH radical scavenging rate was 85.34%，84 points for the sensory evaluation；Persimmon oral tablet antioxidant capacity were significantly higher than the antioxidant capacity of natural made of persimmon，and with the increase in the concentration of antioxidant capacity increased.