Abstract:Anti-tumor effect of plant fermentation extract（PFE）on S180 tumor-bearing mice was studied and the possible mechanisms were explored.Kunming mice transplanted with S180 cells were treated with a PFE via intragastric administration.Reagent kits of triglyceride and total-cholesterol were employed for concentration detection in the serum.Contents of carnitine acylcarnitine translocase（CAT），malondiadehyde（MDA）and superoxide dismutase（SOD）in the serum were examined.The MTT method was used in the spleen lymphocyte transformation experiment and LDH was used to detect the NK cell activity.The inhibition ratios of PFE among the 3 treatment groups were 18.2%，25.5%and 52.7%，respectively.However，the treatments showed no significant differences compared to the control in variables of T cell activity，NK cell activity，total-cholesterol content and body weight.High PFE concentration significantly reduced triglyceride level and spleen index（P＜0.05）.Lastly，both low and high PFE concentrations enhanced the antioxidation capacity of S180-bearing mice. The PFE was demonstrated to possess anti-tumor effects in the present in vivo study.Both improved immune response and antioxidation abilities appeared to be responsible for the effects，while further investigation is needed in the future.