Abstract:To explore the effects of aqueous extract from chrysanthemum morifolium of Chuju on visceral fat accumulation and oxidative stress induced by high-fat diet. Three-week old ICR mouse weighing [（10±2） g] were divided into three groups， seven for each group； groupⅠ：received normal diet， groupⅡ：received high-fat diet， and groupⅢ： cotreated with high-fat diet and Chuju aqueous extract. All animals were fed for 8 weeks， and measured the body weight at the end， then separated the visceral fat pad and weighed it after sacrificing mouse to calculate the ratio of fat to body mass. Blood samples were taken for measurement of serum levels of MDA， GSH and the enzymatic activities of SOD， CAT. Compared by control， the high-fat diet group showed larger ratio of weight of visceral fat to body， higher serum MDA level， but lower level of GSH and reduced enzymatic activities of SOD and CAT； however， compared with the latter， the above effects of high-fat diet were reversed by exposure to aqueous extract of Chuju. Results described above suggest that high-fat diet could trigger visceral fat accumulation and oxidative stress which being inhibited with co-treatment of Chuju aqueous extract.