Abstract:Mycotoxin contamination poses a serious threat to global food safety and public health，making the development of efficient and sensitive detection methods critically important.Metal-organic frameworks（MOFs），owing to their high specific surface area，tunable pore structures，and facile functionalization，have demonstrated significant application potential in the separation，enrichment，and detection of mycotoxins.This article systematically reviewed the synthesis methods of MOFs and their applications in sample pretreatment and mycotoxin detection，with particular emphasis on recent advances in novel MOF-based electrochemical，fluorescence，colorimetric，and surface-enhanced Raman scattering sensors for the detection of various mycotoxins.In addition，the advantages，limitations，and future development directions of existing methods were discussed，with the aim of providing references for the development of efficient mycotoxin detection technologies.