Abstract:Three medicinal and edible homologous materials were taken as research subjects，namely roots of Imperata cylindrica var. major，roots of Phragmites communis Trin.，and Hordeum vulgare L. The fermented extracts of three materials were obtained by microbial fermentation. These fermented extracts were subject to antioxidant activity and antiglycation analysis by adding them to cookies. The generally recognized as safe（GRAS） bacterium Bacillus amyloliquefaciens IT-45 was used to ferment the three materials，with fermented extracts collected by freeze drying. The composition and content of the components in the fermented extract were determined. The structure of the fermented extracts was characterized by UV and Fourier transform infrared spectroscopy. In vitro antioxidant activity was also investigated. The results showed that the total sugar content in the fermented extracts of the three materials was 45.10%，21.81%，and 16.42%，respectively. The protein content was 6.40%，11.28%，and 6.36%，respectively. The phenolic content was 14.90%，29.40%，and 29.89%，respectively. In vitro antioxidant activity study showed that the scavenging ability and total reducing power of roots of P. communis，and H. vulgare against ABTS+，DPPH，and hydroxyl radicals were superior to those of roots of I. cylindrica. For inhibitory rate on fluorescent advanced glycation end products （AGEs），similar results were found in cookies added with fermentation extracts of roots of I. cylindrica and H. vulgare，while the highest inhibitory rate of 16.66% was observed in cookies added with fermentation extracts of roots of P.communis. These findings indicated favorable antioxidant activity and antiglycation efficacy in the fermentation extracts of the three medicinal and edible homologous materials.