Abstract:Sodium hyaluronate is the sodium salt form of hyaluronic acid，exerting regulatory effects on multiple physiological functions such as structural support，moisturization and lubrication，immune regulation，and tissue repair of the human body.In 2021，sodium hyaluronate was officially approved as a novel food ingredient in China and has since been widely applied in the food industry.Therefore，determining sodium hyaluronate content in food is of great significance for food safety and public health.At present，a variety of analytical methods have been developed for the quantification of sodium hyaluronate at home and abroad，mainly including the sulfuric acid-carbazole method，high-performance liquid chromatography，ion-selective electrode technology，nearinfrared spectroscopy，safranine T resonance Rayleigh scattering，ultra-high-performance liquid chromatographytandem mass spectrometry，and enzyme-linked immunosorbent assay.This paper reviewed the analytical methods for sodium hyaluronate content in food in recent years，as well as the application status，principles，applicable scopes，advantages，and disadvantages of various analytical technologies. In addition，the challenges and development prospects of quantification of sodium hyaluronate in food were discussed. The review provided a reference for relevant research and applications.