Abstract:To explore the inhibitory effect of common edible medicinal materials on xanthine oxidase （XO） in Cantonese Laohuo soup， this paper extracted eight common edible medicinal materials with 75% ethanol and water， determined the extraction rate of their crude extracts and the ability to inhibit the activity of XO， and investigated the inhibitory mechanism of different edible medicinal material extracts on XO. The results showed that the extraction rate of the aqueous extracts from seven edible medicinal materials was greater than that of the alcoholic extracts. The alcoholic and aqueous extracts of Smilax glabra Roxb. and the alcoholic and aqueous extracts of Bombax ceiba Linn. were more stable， and the difference in the yield of the two crude extracts was smaller than that of the other edible medicinal materials. The half maximal inhibitory concentration（IC50） of the crude extracts of the 16 edible medicinal materials was in the range of 124.27-2 232.00 μg/mL；the alcoholic and aqueous extracts of Smilax glabra Roxb. and the aqueous extract of Bombax ceiba Linn. were reversible inhibitors primarily based on competitive inhibition for XO， and the alcoholic extract of Bombax ceiba Linn. was a competitive reversible inhibitor.