Abstract:Oral hypoglycemic drugs and insulin injections are commonly adopted for treating diabetes， but they both require long-term use and have significant side effects. Natural hypoglycemic substances， due to their lower toxicity and side effects， are suitable for long-term use and have become a research hotspot. This review analyzed the Pharmacopoeia of the People′s Republic of China and relevant notifications issued by the Ministry of Health to identify medicinal and edible substances with hypoglycemic effects. By searching for the China National Knowledge Infrastructure （CNKI） database from the past decade， a detailed analysis was conducted on the properties of these substances and the frequency of reports validating their hypoglycemic effects.Folium Mori， Concha Ostreae， Radix Puerariae， and Rhizoma Dioscoreae ranked among the most frequently reported substances with hypoglycemic effects. This review also conducted keyword searches on active ingredients， prebiotics， probiotics， and postbiotics. Several polysaccharides， saponins， flavonoids， polyphenols，and alkaloids with hypoglycemic effects were listed， and their hypoglycemic effects were summarized. Additionally， probiotic strains with reported hypoglycemic effects were enumerated， along with prebiotics and postbiotics reported to have hypoglycemic effects. This review provided a certain scientific basis for the personalized selection and rational combination of natural hypoglycemic substances.