Abstract:In this study，CAP?40 was isolated from Choerospondias axillaris at an ethanol content of 40%（vol?ume concentration），and its antioxidant，hypoglycemic and hypolipidemic effects in vitro were preliminarily evaluated.The molecular weight and monosaccharide composition of CAP?40 were determined by high perfor?mance gel permeation chromatography and high performance anion exchange chromatography，respectively.The scavenging rates of DPPH·and ABTS+·，the inhibition rates of α?glucosidase and α?amylase，the binding rates of sodium glycine and sodium taurocholate，as well as the inhibition rate of pancreatic lipase were also determined.The results indicated that the elution curve of CAP?40 was a single symmetric peak with a molecu?lar weight of about 156 206 Da，and the monosaccharides were mainly composed of glucose，galacturonic acid，galactose，arabinose and rhamnose with molar percent of 40.8%，40.7%，9.3%，5.1%，2.0%.When the concentration of CAP?40 was 1.0 mg/mL，the scavenging rates of DPPH· and ABTS+· were（88.85±0.49）%and（87.13±1.63）%，respectively.The inhibitory rate of CAP?40 on α?glucosidase was（71.28±2.34）% at 16.0 mg/mL，and（72.29±4.85）%at 8 mg/mL on α?amylase.In addition，the inhibitory rate of CAP?40 on pan?creatic lipase was（26.34±1.41）% when the mass concentration was 20 mg/mL.The binding rates of sodium glycine and sodium taurocholate reached（31.87±4.53）% and（38.98±0.60）% at 5 mg/mL，respectively.In summary，CAP?40 has certain antioxidant，hypoglycemic and hypolipidemic effects in vitro，which provides a theoretical basis for the development of natural hypoglycemic and hypolipidemic functional foods and also pro?vides new ideas for the comprehensive development and utilization of Choerospondias axillaries resources.