Abstract:Foodborne pathogens are pathogenic bacteria that can cause food poisoning or take food as the transmission medium，which widely exist in all kinds of food substrates and can survive for a long time during food processing and transportation.The ingestion of contaminated food can cause various diseases and seriously threaten human health.In recent years，the DNAzyme biosensor based on functional nucleic acid has been widely used in the field of pathogen detection because of its high stability，easy synthesis and modification，low cost and other technical advantages，which facilitates the development of pathogen detection technologies based on colorimetry，fluorescence and electrochemistry.Based on the research progress on the DNAzyme biosensor in the detection of foodborne pathogens in recent years，the present study reviewed two detection mechanisms of DNAzyme and introduced the classification and application of DNAzyme，aiming to provide references for the detection of foodborne pathogens.