Abstract:This study was designed to investigate the effect of walnut kernel，pellicle and partition on memory in mice.Eighty-eight male Kunming mice were randomly divided into normal control，model and experimental groups.After 36 d of continuous gavage，the mice's ability of motor exploration and learning and memory were examined by open field test and Morris water maze test.After the above behavioral experiments，the total cholesterol（TC），triglycerides（TG），high-density lipoprotein（HDL），and low-density lipoprotein（LDL）of blood lipids in mice were determined.The results showed that in open field test，walnut kernel high-dose group and walnut partition high-dose group had a higher number of crossed squares and times mouse standing on its hind limbs（P ＜ 0.05）compared with the model group and the normal control group.The Morris water maze test indicated that walnut kernel，walnut pellicle and walnut partition high-dose groups used shorter time than the normal control group（P ＜ 0.05）.Walnut has the trend of decreasing the content of serum TC and LDL in mice，and high dose of walnut pellicle lowered the content of serum TC in mice（P ＜ 0.05）.The content of HDL in mice was increased by gavaging walnut partition（P ＜ 0.05）.This study suggested that proper consumption of walnut kernel，pellicle and partition could improve the memory，exercise and exploration ability of mice and regulate blood lipids.