Abstract:China is a major producer and consumer of shellfish.In recent years，food allergies caused by eating shellfish have been increasing.Shellfish allergy often occurs in adults，and usually continues to affect people throughout their lives.It is a food safety issue that has to be paid attention to.Therefore，it is of great significance to study tropomyosin，the main allergen of shellfish，and to develop hypoallergenic or desensitized products.This paper summarized studies on allergenic subtraction technology of tropomyosin from shellfish，introduced in detail the main allergen tropomyosin in shellfish，and focused on summarizing the allergenic subtraction technology of tropomyosin.It also highlighted the future needs and challenges to solve the issue of shellfish allergens，and provided theoretical guidance for the research and development of hypoallergenic or desensitized shellfish products in China.