Abstract:Immune regulation refers to the process by which the body relies on the immune system to recognize and remove antigenic substances and maintain the body's physiological balance and relative stability.With changes in lifestyle，most people have experienced adverse symptoms due to immune regulation disorders.Therefore，the use of immunomodulatory substances in food to regulate the body's immune system has become a focus of research.Among the 18 functions that can be declared in health food in China，the immune regulation function has become one of the most concerning.This article reviews the research progress of active substances with immunomodulatory functions in food and their immunomodulatory mechanisms，while introducing the existing foods with immunomodulatory functions.This article aims to provide a theoretical basis for the further development and utilization of immunomodulatory substances and the development of foods with immunomodulatory functions.