Abstract:The improved QuEChERS（Quick，Easy，Cheap，Effective，Rugged，Safe）method was used to extract and purify aquatic samples，with the goal of establishing a rapid detection method for N-nitrosamine compounds by gas chromatography-mass spectrometry.Samples were treated with acetylene and positive hexane，and a DB-WAX column was used inthe multiple reaction monitoringmode to carry out the legal amount of the outer label.Four N-nitroamine compounds were isolated displayed good linear relationships ranging from 1.00 μg/L to 1 000 μg/L[correlation coefficient（r）>0.998].The recoveries were 89.0% to 104.2%.The relative standard deviations were 0.6% to 2.2% （n=6）.The improved QuEChERSmethod was simple to operate，required only small amounts of sample and reagent，had a short pre-processing time，and was very accurate.The improved method could detect N-nitrosamine compounds in aquatic products.