Abstract:The optimal concentration of Zn2+was determined with respect to stability.The effects of the aqueous:alcohol volume ratio，ratio of wall materials（mass ratio of Arabic gum ∶zein），and ratio of core ∶wall（mass ratio of curcumin∶zein-Arabic gum）on the preparation of curcumin nanoparticles were determined by observing the embedding rate.Nanoparticle preparation was optimized using L9 （34）orthogonal studies based on singlefactor experiments，with the optimal process obtained using the multi-index comprehensive balance method.Furthermore，the effect of microencapsulation on the photostability of curcumin solution was analyzed，with the addition of 0.3 g/L Zn2+improving the photostability.The optimal preparation of curcumin nanoparticles was as follows:the water:alcohol volume ratio was 3∶1，the mass ratio of wall materials was 8∶10，and the mass ratio of core:wall was 7∶100.Under these conditions，the embedding rate of curcumin nanoparticles was up to 95.844%，the drug loading was 62 mg/g，and the particle size was 0.994 μm.The photolysis of the embedded curcumin nanoparticles was slower than that of the unembedded nanoparticles.Therefore，the stability of curcumin under light was improved by microencapsulation.