Abstract:Selenium is a critical micronutrient for human health that plays a significant role in anticancer and delaying aging.Lactic acid bacteria（LAB）can regulate the intestinal flora，and play an anti-tumor and antioxidant activity.Lactic acid bacteria enrich and convert inorganic selenium into organic selenium in the culture system.Systematic studies by researchers were made on the effect factors of selenium enrichment of lactic acid bacteria and the biological activity of selenium-enriched products.The selenium-enriched ability，transformation of selenium fractions，biological activity of selenium-enriched products of LAB were summarized in this paper and developing prospect was also discussed briefly here.Further study on bioactivity evaluation of selenium-enriched products and the mechanism of selenium enrichment of LAB based on molecular biomethods were important aspect in future.