Abstract:Total phenol from Magnolia officinalis flowers was used as an indicator for evaluating the efficiency of the M.officinalis flower extraction process、a combination of statistical methods were employed for analysis：a single-factor method，plackett-burman test，steepest climb design，and response surface methodology.Results revealed that the optimal extraction conditions were as follows:material-to-liquid ratio was 1∶30（g/mL）、extraction temperature was 94 ℃、raw material particle size was 100 mesh、extraction time was 7 min and number of extractions was 1.Under these conditions，the total phenol content extracted from M.officinalis flowers（6.42%）was close to the theoretical value（6.50%），indicating that the optimized process has practical application value.