Abstract:Models of diabetic rats were established by high sugar and high fat diet and intraperitoneal injection of streptozotocin，then the rats were fed with the whole wheat flour（WWF）for 12 weeks.During the experiment，fasting blood glucose（FBG）was detected regularly and oral glucose tolerance test（OGTT）was conducted. At the end of the experiment，glycosylated hemoglobin（HbA1c），total cholesterol （TC），triglyceride（TG），high density lipoprotein cholesterol（HDL-C），low density lipoproteincholesterol（LDL-C），total tuperoxidedismutase（T-SOD），catalase（CAT），malondialdehyde（MDA），free fat acid（FFA）and high sensitivity C-reactive protein （hs-CRP）were detected，and the livers of the rats were observed pathologically. Compared with the model control group，the FBG，HbA1c，TC，TG，LDL-C，MDA and FFA contents of the experimental group were significantly reduced，the SOD，CAT contents and glucose tolerance were significantly increased，the degree of liver injury was reduced，and the level of hs-CRP was little changed. In summary，the WWF can effectively reduce the level of blood glucose and lipid，improve its antioxidant capacity and reduce liver damage.