Abstract:The present study examined the effects of Kaili red sour soup on lipid metabolism and oxidative stress in obese rats using the obese rats induced by high-fat diet.The obese rats model was established by feeding a high-fat diet，and then the rats were treated with Zhibituo and different doses of Kaili red sour soup for 12 weeks.The body weight of rats，and the levels of triglyceride （TG），total cholesterol（TC），low density lipoprotein cholesterol（LDL-C）and high density lipoprotein cholesterol（HDL-C）in serum were measured.Liver tissue pathology was observed by hematoxylin eosin （HE）staining.The contents of total antioxidant capability（T-AOC），superoxide dismutase（SOD）and malondialdehyde（MDA）in serum and liver were determined.The results showed that compared with the model group，Kaili red sour soup reduced significantly the body weight，reduced the contents of TG，TC and LDL-C in serum，increased the content of HDL-C （P<0.05），and reduced hepatic lipid accumulation.In addition，Kaili red sour soup administration elevated the activities of the T-AOC and SOD in serum and liver of obese rats，and a significant decrease of the levels of the lipid peroxidation product malondialdehyde（MDA）was observed（P<0.05）.The above results indicated that Kaili red sour soup could decrease the level of blood lipid in obese rats induced by the high-fat diet，and improved hepatic pathological damage.It could also be helpful in reducing oxidative stress，improving antioxidant levels.