Abstract:Fungal polysaccharides have been intensively investigated for a long time，which exhibited a wide range of biological activities.Poria cocos-derived polysaccharides，which were obtained from the sclerotia of Poria cocos，have been proven to have various bioactivities such as immunomodulation，anti-tumor，antiinflammation，anti-oxidation，etc.In this paper，the extraction methods，structure，functional activities and the corresponding mechanism of Poria cocos polysaccharides as well as the safety assessment were reviewed.Finally，the application prospect of Poria cocos-derived polysaccharides was discussed.