Abstract:The ionic liquid and inorganic salt system which could be used in the extraction of mulberry leaf polysaccharide were selected，and the best extraction technology of mulberry leaf polysaccharide was obtained.15 kinds of ionic liquids such as 1-butyl-3-methylimidazolium tetrafluoroborate，1-octyl-3-methylimidazolium hexafluoro phosphate，glutamic acid bis （trifluoromethanesulfonyl）imide were added into 13 kinds of inorganic salts，such as potassium dihydrogen phosphate，anhydrous sodium carbonate，sodium thiosulfate，to form aqueous two-aqueous phase.The effects of ionic liquid concentration，extraction temperature，extraction time and solid-liquid ratio on the extraction of polysaccharides from mulberry leaves were studied by single factor experiment.According to response surface design experiment and verification experiment，the optimal extraction conditions of mulberry leaf polysaccharide were obtained as follows：ionic liquid concentration of 0.000 3 mol/L，extraction temperature of 76℃，solid-liquid ratio 1∶20（g/mL），extraction time 109 min.